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Dr. C. Garner is pursuing the question how abnormal synaptic signaling leads to cognitive dysfunction in mouse models of Down syndrome. More » |
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Using genetic tools Dr. T. Huang hopes to learn more about how genetic modifiers modulate the disease process in Down syndrome. More » |
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By studying the behavior of Down syndrome mice in experimental settings, Dr. L. Jacobs is trying to understand cognitive decline such as spatial memory deficits. More » |
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Dr. D Madison is utilizing electrophysiological and molecular genetic approaches to understand the molecular mechanisms underlying normal and abnormal neurotransmission in mouse models of Down syndrome. |
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Using electrophysiological, anatomical and molecular techniques Dr. R. Malenka is elucidating the abnormalities in neuronal communication in various mouse models of Down syndrome. More » |
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To understand the molecular and cellular mechanisms underlying cognitive problems in Down syndrome, Dr. E. Masliah is studying the ultrastructure of mouse synapses. |
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The main question pursued in Dr. W. Mobley's laboratory is which gene(s) are responsible for abnormal structure and function of synapses in Down syndrome. More » |
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To examine how genetic factors, brain structure and function, and environmental factors impact the development and progress of individuals with Down syndrome, Dr. A. Reiss uses advanced research tools such as neuroimaging, genetic analyses and neurobehavioral assessments. More » |
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Dr. R. Tsien employs various research methods such as electrophysiology, imaging, and cDNA arrays to explore the idea that abnormal synaptic signaling between neurons may cause cognitive dysfunction in Down syndrome. More » |
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Dr. T. Wyss-Coray is taking advantage of mouse models to find ways in which the brain's own immune mechanisms can be used to protect against Alzheimer's disease related neurodegeneration in Down syndrome. More » |
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With the help of mouse models, Dr. Y. Yang's laboratory is defining molecular and cellular mechanisms important for maintaining and sustaining neurons that may degenerate in Down syndrome. More » |
