In practice, a research team is required to tackle the problem from a variety angles. This is why we have assembled a talented team of scientists and clinicians at our center. Each researcher is studying the problem on a different level: from genes, to molecules, to cells, to neuronal circuits, and to the whole brain. With this collaborative effort, we hope to eventually put all the puzzle pieces together. Once we have identified which genes are responsible for the cognitive deficits and understand how increased activity of these genes influences cognition, we will try to find treatments that decrease this activity. Each new research lead will be pursued as rapidly as possible. We intend to accelerate the application of research advances to the care of people with Down syndrome.